纳米生物光子学（Nanobiophotonics）是融合物理、化学、信息与生命科学的交叉学科，旨在利用光学与纳米光子学的优势，发展面向生命体系研究的新技术。典型技术包括光镊、超分辨成像和纳米光子学传感等，在单分子、生物大分子及活细胞层面的操控、成像与分析中发挥着核心作用。近年来，随着纳米材料与光学探测技术的进步，多功能纳米光学探针不断涌现，使纳米尺度的温度、力场及磁场成像成为可能，推动了生命科学与光学前沿的深度融合。然而，在复杂生物环境中实现对单颗粒和细胞器的高分辨成像与精确操控仍面临挑战。本团队聚焦于研究和利用新型微纳结构与材料的独特光学性质，发展创新型生物光子学技术，以解决亚细胞生物物理研究中的关键科学问题。

目前团队成员5人，包括1位国家级青年人才，1位教授，2位副教授和1位助理教授，团队负责人王帆教授。以通讯作者发表文章100余篇，含Nature Photonics, Nature Nanotechnology，Nature Protocols, Nature Communications，Light: Science & Applications，Optica，Nano Letters，和Advanced Materials。成果入选中国光学十大进展与中国光学十大社会影响力事件。主持多项国家自然科学基金，包含重点项目。成员受聘担任APL Photonics 青年编委，Journal of Modern Optics编委，中国激光编委， Chinese Optics Letters编委，中国稀土学报青年编委。负责人王帆教授曾获得澳大利亚青年学者奖（DECRA）、澳大利亚David Syme研究奖以及iCANX青年科学家奖。

主要研究方向：光镊、超分辨成像、上转换纳米颗粒、微腔光子学

代表性成果：

1. Shan, X.; Ding, L.; Wang, D.; Wen, S.; Shi, J.; Chen, C.; Wang, Y.; Zhu, H.; Huang, Z.; Wang, S. S. J.; Wang, F. Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy. Nature Photonics, 18(9), 913–921 (2024).

2. Shan, X.; Wang, F.; Wang, D.; Wen, S.; Chen, C.; Di, X.; Nie, P.; Liao, J.; Liu, Y.; Ding, L.; Jin, D. Optical tweezers beyond refractive index mismatch using highly doped upconversion nanoparticles. Nature Nanotechnology, 16(5), 531–537 (2021).

3. Wang, F.; Wen, S.; He, H.; Wang, B.; Zhou, Z.; Shimoni, O.; Jin, D. Microscopic inspection and tracking of single upconversion nanoparticles in living cells. Light: Science & Applications, 7(4), 18007 (2018).

4. Tian, M.; Liu, B.; Lu, Z.; Wang, Y.; Zheng, Z.; Song, J.; Zhong, X.; Wang, F. Miniaturized on-chip spectrometer enabled by electrochromic modulation. Light: Science & Applications, 13(1), 278 (2024).

5. Lu, Z.; Hang, X.; Zhao, Z.; Cheng, L.; Zeng, Y.; Li, B.; Tian, M.; Liu, B.; Shan, X.; Zhu, H.; Wang, F. Photoenergy harvesting by ammonium molybdate soft hydrogel drops. Light: Science & Applications, 14(1), 372 (2025).

6. Chen, C.; Wang, F.; Wen, S.; Su, Q. P.; Wu, M. C. L.; Liu, Y.; Wang, B.; Li, D.; Shan, X.; Kianinia, M.; Jin, D. Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles. Nature Communications, 9(1), 3290 (2018).

7. Liu, Y.; Zhou, Z.; Wang, F.; Kewes, G.; Wen, S.; Burger, S.; Wakiani, M. E.; Xi, P.; Yang, J.; Yang, X.; Jin, D. Axial localization and tracking of self-interference nanoparticles by lateral point spread functions. Nature Communications, 12(1), 1–9 (2021).

8. Chen, C.; Liu, B.; Liu, Y.; Liao, J.; Shan, X.; Wang, F.; Jin, D. Heterochromatic nonlinear optical responses in upconversion nanoparticles for super-resolution nanoscopy. Advanced Materials, 33(23), 2008847 (2021).

9. Ding, L.; Chen, C.; Shan, X.; Liu, B.; Wang, D.; Du, Z.; Zhao, G.; Su, Q. P.; Yang, Y.; Halkon, B.; Jin, D. Optical nonlinearity enabled super-resolved multiplexing microscopy. Advanced Materials, 36(2), 2308844 (2024).

10. Lu, Z.; Zhu, H.; Wang, D.; Ma, M.; Wang, J.; Zhong, X.; Wang, F. Moisture-light harvesting enhanced hydrovoltaic electric generation. Advanced Materials, e15241 (2025).

11. Liu, B.; Wang, F.; Chen, C.; Dong, F.; McGloin, D. Self-evolving ghost imaging. Optica, 8(10), 1340–1349 (2021).

12. Ding, L.; Shan, X.; Wang, D.; Liu, B.; Du, Z.; Di, X.; Chen, C.; Maddahfar, M.; Zhang, L.; Shi, Y.; Jin, D. Lanthanide ion resonance–driven Rayleigh scattering of nanoparticles for dual-modality interferometric scattering microscopy. Advanced Science, 9(32), 2270207 (2022).

13. Li, X.; Wang, Y.; Shi, J.; Zhao, Z.; Wang, D.; Chen, Z.; Cheng, L.; Lu, G.-H.; Liang, Y.; Dong, H.; Wang, F. Large-area near-infrared emission enhancement on single upconversion nanoparticles by metal nanohole array. Nano Letters, 24(19), 5831–5837 (2024).

14. Song, J.; Liu, B.; Wang, Y.; Chen, C.; Shan, X.; Zhong, X.; Wu, L.-A.; Wang, F. Computational and dark-field ghost imaging with ultraviolet light. Photonics Research, 12(2), 226–234 (2024).

Wang, Y.; Liu, B.; Ding, L.; Chen, C.; Shan, X.; Wang, D.; Tian, M.; Song, J.; Zheng, Z.; Xu, X.; Wang, F. Multi-photon super-linear image scanning microscopy using upconversion nanoparticles. Laser & Photonics Reviews, 18(12), 2400746 (2024).